admin isbra esbra

Hendershot CS1,2, Wardell JD1, Ramchandani VA3

1Centre for Addiction and Mental Health, Toronto, Canada
2University of Toronto, Toronto, Canada
3National Institute on Alcohol Abuse and Alcoholism, Bethesda, USA

Individual differences in subjective and behavioral responses to alcohol are implicated in the risk for alcohol use disorder (AUD) and alcohol-related harms. Prior human laboratory studies suggest that trait impulsivity (or related indicators of behavioral disinhibition) may predict variation in acute responses to alcohol. Although these findings have implications for AUD etiology, few studies have investigated these phenomena in drinkers under age 21, and few studies have included measures of laboratory self-administration. This presentation describes the examination of impulsivity-related traits in relation to subjective and behavioral outcomes during intravenous alcohol administration and self-administration paradigms. In Study 1, indicators of trait disinhibition (ADHD symptoms, impulsivity, and sensation seeking) were examined as predictors of changes in cognitive control and subjective responses during an alcohol clamp procedure. Participants (N=88, M=19.8 years, SD=0.8) completed a cued go/no-go task and measures of stimulation, sedation and craving at repeated intervals. Multi-level modeling demonstrated that higher reported ADHD symptoms and higher sensation seeking correlated with greater impairments of inhibitory control across the session. Additionally, ADHD symptoms related to greater increases in stimulation during the ascending limb. In Study 2, a subset of participants (N=60) completed a 2-hour free-access intravenous self-administration session. ADHD symptoms, impulsivity, sensation seeking, and self-reported impaired control were examined as correlates of self-administration, and as moderators of the association between craving and self-administration. Although none of these factors predicted self-administration directly, trait impaired control moderated the within-person association between craving and subsequent BrAC, such that the positive association between craving and subsequent BrAC was stronger among participants higher on trait impaired control. These results provide further information about impulsivity-related traits as moderators of behavioral and subjective responses to acute alcohol in youth, including initial evidence suggesting that trait impaired control moderates the association between subjective craving and ensuing self-administration.